Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase ε/PRSS22
نویسندگان
چکیده
From the Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115; Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94143; Department of Pediatrics, Magee-Women’s Research Institute, and University of Pittsburg, Pittsburg, PA 15213; Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030; and Department of Immunology, Allergy, and Infectious Disease, St. George Hospital and University of New South Wales, Kogarah NSW 2217, Sydney, Australia
منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase /PRSS22
Tryptase is a member of the chromosome 16p13.3 family of human serine proteases that is preferentially expressed by epithelial cells. Recombinant pro– tryptase was generated to understand how the exocytosed zymogen might be activated outside of the epithelial cell, as well as to address its possible role in normal and diseased states. Using expression/site-directed mutagenesis approaches, we no...
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